Health Research Board Clinical Research Coordination Ireland, HRB-CRCI, is an independent integrated national clinical research network, providing centralised support in the conduct of multicentre clinical trials (both commercial and academic) across Ireland. It is funded by extramural grants from the Health Research Board (HRB) and Enterprise Ireland (EI), supported by the five largest Irish Universities and is hosted by Clinical Research Development Ireland (CRDI).

In 2014, the Directors of five University Clinical Research Facilities/Centres (CRF/Cs) responded to a HRB and EI invitation to submit a proposal for the development of a network to support the conduct of multicentre clinical trials across the island of Ireland. Their application was successful, and led to the establishment of HRB CRCI as a collaborative partnership of the five university based CRF/Cs and their associated hospitals.

The HRB CRCI central office gives overarching support and expertise to manage and coordinate the networks activities. The partner CRF/Cs provide the infrastructure, physical space and facilities and experienced research and specialist support staff needed for the successful conduct of world-class patient-focused research.