HRB-Trials Methodology Research Network (HRB-TMRN)

Logo 10 - CopyThe conduct of clinical trials needs to become more efficient and effective if they are to lead to successful and effective patient care. The right trials need to be chosen, implemented and reported in the right way.

HRB-TMRN is a collaborative initiative between a number of Irish and international higher education institutes and methodology centres. Its mission is to strengthen the methodology and reporting of trials in health and social care in Ireland so that they become more relevant, accessible and influential for patients and other service users, practitioners, policy makers and the public.

The network provides practical trial methodology advice on grant applications, training and education, online support services as well as involvement in primary trial methodology research.

Research and innovation: HRB-TMRN are involved in conducting trial methodology research across a number of clinical trials into issues around design, conduct, analysis and dissemination of trials. The network also offers annual funding for primary methodology research in the form of funding for Studies within a Trial (SWAT) and undergraduate summer scholarships.

Training and educationHRB-TMRN educational events include; webinars, an annual trial methodology symposia, short courses, online modules and a variety of online resources.

Support: HRB-TMRN will help researchers by providing advice on challenging aspects of trial methodology and reporting of trials. This will provide opportunities to establish new collaborations for methodology research. HRB-TMRN provides this advice and support through the Trial Methodology and Reporting Advisory Service (TMRAS). The TMRAS provides trial methodology advice to trialists who encounter methodological problems outside of the standard design of clinical trials.



What HRB TMRN offer

  • The provision of training and education from international experts in trial methodology.
  • International expertise in evidence synthesis including meta-analyses.
  • Involvement in Feasibility and Definitive Intervention grant proposals as Co-applicant and Collaborator, embedding primary methodology research within proposals, which is cost effective and adds value to your proposal.
  • Access to an experienced qualitative methods research team for embedding qualitative research in your trials.
  • Significant expertise in the development of Core Outcome Datasets.
  • Support and advice on the challenging aspects of trial methodology with expertise across several areas including trial design and analysis, reporting and dissemination of findings and health economic evaluation.

Examples of current research projects

  • Randomised trial of recruitment methods in Irish Primary Care (Study within a trial – SWAT)
  • Randomised trial of Skype based tele-monitoring versus standard monitoring (Study within a trial – SWAT)
  • Methods of dissemination of research evidence
  • Development of Core Outcome Datasets
  • Risk adapted approaches to clinical trial monitoring
  • The role of context in the implementation of healthcare interventions
  • Methods to influence the completeness of response to self-administered questionnaires (Cochrane Systematic Review)