HRB CRCI works with and supports a number of clinical research networks. Clinical research networks are groups of clinicians and scientists from across Ireland who have come together around a particular disease, or clinical interest. Investigators agree on research activities that are best conducted as a large group nationally rather than in isolation.
A number of clinical research networks have been established and are listed below by research area. Some receive state funding while others are funded mainly through charitable funds. The Health Research Board in recent years have funded the establishment of four Clinical Trial Networks in Stroke, Critical Care, Perinatal Care and Primary Care.
The clinical research network page is live and updated on an ongoing basis. If you are a lead of a clinical research network and would like it included on the HRB CRCI website please contact firstname.lastname@example.org
Further information on the different networks are provided below by research area.
Cancer Trials Ireland
Established in 1996, Cancer Trials Ireland, formally the All-Ireland Cooperative Oncology Research Group (ICORG), enables patients in Ireland to gain early access to novel cancer treatments and therapies. Cancer Trials Ireland operate cancer clinical trials across a number of disease areas – Breast, Gastrointestinal, Genitourinary, Gynaecology, Haematology/Lymphoma, Lung, etc. They work closely with international collaborative groups such as ECOG, NSABP, ANZUP and also have developed strong links with our pharmaceutical partners.
BCNI: Blood Cancer Network Ireland
BCNI is a national clinical research network set up to benefit blood cancer patients in Ireland. BCNI offer clinical trials to blood cancer patients, providing the opportunity to test new, potentially life-saving treatments and drugs. BCNI has also established a biobank and blood cancer registry, which will further our knowledge and expertise in the field of blood cancer research and ultimately improve patient outcomes. BCNI has been funded by the Irish Cancer Society and Science Foundation Ireland since 2015.
BCNI is a collaborative network of clinicians, scientists, and population health experts with a shared interest in blood cancer research. Members of the national network are based at the NUI Galway/ University Hospital Galway, University College Cork/ Cork University Hospital, Trinity College Dublin/St James Hospital, Beaumont Hospital and the Mater Hospital, and the National Cancer Registry Ireland. The key investigators involved are Dr Eva Szegezdi, Dr Philip Murphy, Prof. Mary Cahill, Prof. Michael O’Dwyer, Prof. Paul Browne, Prof. Peter O’Gorman, Prof. Kerri Clough-Gorr and Dr John Quinn
The aim of BCNI is to provide blood cancer patients in Ireland with access to novel and innovative cancer treatments through the provision of early phase clinical trials. BCNI also collect information and samples from blood cancer patients in Ireland in order to improve our understanding and to uncover new ways to combat this disease.
For general enquiries phone: +353-91-49-3811 or email BCNI@nuigalway.ie
HRB Stroke Clinical Trial Network Ireland
Stroke is the second leading cause of death in the world, the leading cause of new disability, and a major cause of dementia and health costs.
The HRB Stroke Clinical Trial Network Ireland is led by Professor Peter J Kelly, Mater University Hospital and University College Dublin. The Network will initially involve eight Irish hospitals, six leading universities, and all seven Hospital Groups, including colleagues from UCD, RCSI, Trinity College, UCC, NUI Galway, and University of Limerick. It will have strong links with international researchers in the UK, Europe, and North America. In addition to the HRB, other Network partners are the Irish Heart Foundation, who will fund new Stroke Research Nurses, and seven industry partners, who will fund education and training activities.
In the Network, Irish researchers in hospitals will:
- Join several new international trials of new treatments for emergency care, prevention, and recovery after stroke.
- Lead a new clinical trial aiming to prevent second strokes and heart attack after first stroke.
- Train new doctors, nurses, and therapists in how to perform safe high-quality clinical trials, and will work with patient groups and the private sector to bring new treatments to patients with stroke.
HRB Irish Critical Care Clinical Trials Network
The HRB Irish Critical Care Clinical Trials Network (HRB ICC-CTN) is led by Professor Alistair Nichol, St Vincent’s University Hospital and University College Dublin.
It was established in 2015 to support research programs being conducted by the Irish Critical Care-Clinical Trials Group (ICC-CTG). The CTN aims to support efforts to conduct high quality clinical trials on the Island of Ireland, based on the opportunity, the science, the feasibility and the ability to enhance the standing of the ICC-CTG to conduct trials and also the ICC-CTN to co-ordinate trials nationally and internationally.
The goal of the ICC-CTN is to improve clinical therapies to improve patient survival and health outcomes among those who are critically ill. Patients involved in the research will have access to the latest innovations in intensive care, helping to ensure future patients benefit from the lessons learned through national and international research which help to inform best practice guidelines.
The group includes the academic leadership in our speciality and encompasses more than 75% of all the ICU capacity in Ireland.
To date, a number of large multi-site international ICC-CTN endorsed trials were recently completed:
PHARLAP – this was a trial to determine whether the way we ‘set’ the breathing machine helps reduce further lung damage in patients with Acute Respiratory Distress Syndrome. This phase II trial was conducted in 34 sites in 5 countries and 115 patients were enrolled as the trial finished early due to a similar trial (the ART study, JAMA) suggesting harm with an open lung approach. However, our results demonstrated that there was no indication of harm to patients by adopting an open lung ventilation approach but overall it didn’t improve outcomes. Future studies may elucidate which patients my receive benefit from this approach – so called responder. We are conducting an analysis of similar trials in Brazil, the US and Australia in an attempt to answer this question.
(Link to PHARLAP publication)
TRANSFUSE – this double-blind randomised controlled trial aimed to determine whether giving ‘fresher’ blood versus ‘older blood’ in transfusions make a difference to patients who are admitted to ICU. This was conducted in 4919 patients in 59 sites in 5 countries and results showed that giving ‘fresher’ blood did not benefit patients. This result was important for informing blood bank practices globally. The shift towards providing freshest available blood has now ceased, with huge blood bank resource / stock implications.
(Link to TRANSFUSE publication)
PEPTIC – this cluster crossover randomised controlled trial aimed to determine which of the common treatments used to help reduce bleeding from the stomach when people are very unwell is best. This was conducted in almost 27,000 patients in 50 hospitals in 5 countries and results demonstrated that proton pump inhibitors compared to H2 receptor blockers for stress ulcers did not significantly improve patient survival. Not only was this trial design novel – we recruited a very large number of patients for a fraction of the normal cost by using established registries to collect patients’ data, but this result could save tens of thousands of lives globally each year.
(Link to PEPTIC publication)
The ICC-CTN also supports ICC-CTG sites to participate in observational studies, and phase II and phase III randomised trials including POSE, WEANSAFE, EPIC III, SPICE III, REMAP-CAP, TEAM, STOP AKI and STARRT AKI. This increases the ability of Irish patients in all ICC-CTG ICU’s to participate in these global research studies
Currently, the ICC-CTN is co-ordinating in Ireland, Europe and Australia / New Zealand (with ANZIC-RC, Monash university) one of the largest randomised controlled trials among cardiac arrest patients to determine whether targeting slightly higher carbon dioxide levels than normal via mechanical ventilation improves neurological outcomes six months after the event.
Furthermore, through this collaboration with the ANZIC-RC, Monash University, the ICC-CTN is co-ordinating one of the largest double-blind placebo-controlled trial of erythropoietin in trauma patients to investigate whether EPO alfa is an effective therapy to improve survival and disability status following traumatic injury.
Another major focus of the network is its commitment to provide education, training and support to researchers in the critical care field in Ireland. A key component of this comes from a global collaboration with InFACT (International Forum for Acute Care Trialists) where the network is helping to bring an intensive care-specific basic research training course to Ireland in 2020.
The network is also committed to further developing its collaboration with patient and public representatives as we believe it to be an integral component of our activities. We are currently doing this through empiric research, representation on patient-public forums and patient-public programs.
Link to ICC-CTN website
Link to ICC-CTG website
Link to ICSI (Intensive Care Society of Ireland) website
Link to ANZIC-RC website
Dementia Research Network Ireland (DRNI)
Prevention, Cure & Care for Neurodegenerative Diseases
Established in 2012, the network was previously known as Dementia and Neurodegeneration Network Ireland. DRNI is an innovative, all-Ireland research initiative which supports and facilitates collaborative interdisciplinary research integrating the basic, clinical and social sciences in dementia and neurodegenerative disease research. DRNI seeks to improve outcomes for people with dementia/ neurodegenerative disease through improving our understanding of the causes and mechanisms of dementia/neurodegeneration, the effectiveness of different models of care, and the policy changes required to improve individuals’ quality of life.
The network currently comprises over 90 members. Membership includes leading Irish academics, clinicians, health & social care practitioners, early-career researchers, government representatives, community & voluntary sector members, people living with dementia and Parkinson’s disease, and carers.
The inter-disciplinary nature of the network reflects the emerging international evidence of the role of multi-modal influences on dementia and neurodegeneration. It reflects the network members’ belief that the integration of knowledge and practice from diverse research traditions has the potential to radically improve our understanding of dementia and neurodegeneration, in relation to prevention, cure and care.
ATLANTIC DiP (Diabetes In Pregnancy)
The ATLANTIC DiP research programme has focused on examining the outcomes of pregnancy for women with Type 1 and Type 2 Diabetes and the factors influencing these outcomes. The mission of ATLANTIC DIP is to improve the outcomes of pregnancy for women with Diabetes by promoting evidence based best practice before, during and after pregnancy.
Galway Diabetes Research Centre (GDRC)
GDRC is a joint venture between NUI Galway and Galway and Roscommon University Hospital Group, which bring together an interdisciplinary research consortium of active researchers and clinicians who have a track record in the field of diabetes. The centre is a hub for collaborative effort of researchers and clinicians, with a passion for this work, to provide a greater understanding of how diabetes develops and the underlying mechanisms, the development of new and better therapies for patients, and assessing health care interventions and delivery for patients.
Investigator Network for Inflammatory Bowel Disease Therapy in Ireland (INITIative)
INITIative is the first collaborative research network for Inflammatory Bowel Disease in Ireland. The network is open to clinical and scientific investigators with an interest in Crohn’s Disease and Ulcerative Colitis throughout the island of Ireland. Goals of the Network include:
- To foster collaboration and encourage multi-centre investigator initiated studies in Crohn’s Disease and Ulcerative Colitis in Ireland
- To attract and facilitate industry sponsored clinical trials in Crohn’s Disease and Ulcerative Colitis in Ireland in order to improve the access for patients in Ireland to investigational drugs and therapies
- To facilitate participation by Irish IBD investigators in European research consortia and networks
- To attract funding for and investment in research infrastructure to support research in Crohn’s Disease and Ulcerative Colitis in Ireland
- To foster all Ireland, European and Global collaboration in IBD research and improve the profile of IBD related research taking place in Ireland
Current INITIAtive projects include recruitment for the ECCO sponsored ICARE study which is the first observational European prospective cohort study that will provide unique information (safety, efficacy, risk- benefit ratio, and healthcare costs) on the long-term use of recommended therapy in IBD.
For further information please contact:
Glen Doherty MB BCh PhD FRCPI FEBGH
Senior Clinical Lecturer, University College Dublin and Consultant Gastroenterologist and Physician, Centre for Colorectal Disease, St. Vincent’s University Hospital
Danielle Mervyn, INITIative Co-ordinator
Centre for Colorectal Disease, St. Vincent’s University Hospital
Established in 2018, VTE Ireland is a National Clinical Venous Thromboembolism (VTE) Working Group of motivated health care professionals focussing on VTE prevention and treatment in Ireland.
Blood clots, usually in the legs or lung are collectively known as Venous Thromboembolism (VTE). In Europe, VTE is responsible for more deaths than AIDS, Breast Cancer, Prostate Cancer and motor vehicle accidents combined.
Through this network, we want to embed VTE risk assessment into daily practice within the Irish health service in an accountable and measurable way and also to improve patient awareness by informing patients of their right to a risk assessment and increasing the awareness of signs and symptoms.
Visit the Irish Network for VTE Research website.
Irish Hepatitis C Outcomes Research Network (ICORN)
Established in 2012, ICORN is a collaboration between clinical specialist groups, patient advocacy groups and healthcare service providers including the Irish Society of Gastroenterology (ISGE), the Infectious Diseases Society of Ireland (IDSI), and the National Centre for Pharmacoeconomics (NCPE). Clinicians from the seven hospitals with centres of excellence in gastroenterology, hepatology or infectious disease caring for patients with Hepatitis C (HCV) infection are involved, they are: Beaumont Hospital, Dublin; Cork University Hospital, Cork; Galway University Hospital, Galway; Mater Misericordiae University Hospital, Dublin; St. Luke’s Hospital, Kilkenny; St. James’s Hospital, Dublin and St. Vincent’s Hospital, Dublin.
The initial goal of this collaboration was to optimise the quality of care of patients with Hepatitis C (HCV) undergoing treatment with direct-acting antiviral therapy (DAAs). This prompted the design and implementation of treatment protocols for clinical sites and the establishment of the ICORN Treatment Registry, a prospective longitudinal treatment outcomes registry. The ICORN Treatment Registry facilitates clinical, basic science and translational medicine research for HCV infection. Other network research themes developed since 2012 include innovative research projects on models of care and screening for HCV infection.
ICORN affords the opportunity for collaborative, multi-centered, world-class research in patients with Hepatitis C in Ireland and is uniquely positioned as the leading platform for HCV clinical research in Ireland.
For further information, please contact:
Dolores Barry, ICORN Programme Manager
Tel: +353 1 896 4038
Motor Neurone Disease:
Research Motor Neurone
Research Motor Neurone (RMN) was founded in 2007, for the purpose of promoting and facilitating research into the causes and treatments of motor neurone disease (MND), also known as ALS. RMN also strives to increase awareness of this incurable disease at both a national and international level. Ongoing research is needed to discover the cause, treatment and methods of improving quality of life for MND sufferers and their families.
Neurology Research Group, St. Vincent’s University Hospital
The Neurology Research Group in St. Vincent’s University Hospital (SVUH) was established over 15 years ago. It has expertise and experience running numerous clinical pharmaceutical trials, academic research studies – both clinical and basic science, and interventional studies with allied health professionals. Several national neurology registries and research databases are also co-ordinated from the SVUH site.
Their particular areas of excellence are neuroinflammatory disorders, in particular multiple sclerosis, movement disorders and cognitive neurology. They have a dedicated clinical facility and can run clinical trials in all other areas of neurology. Their principal Investigators are recognised as international experts in their field of research and are experienced national principle investigators for many clinical trials. In addition to four consultant neurologists, they have a dedicated research team consisting of neurology research registrars, clinical research nurse manager/ coordinator, 3 clinical research nurses and a research assistant. As well as dedicated clinical facilities they have office space for external monitors, laboratory facilities on site for sample processing and access to neuroimaging, neurophysiology, neuropsychology, neuropsychiatry and neuro-ophthalmology services to name but a few. They have on-going collaborations with a number of basic neuroscience and bioengineering groups in Ireland and internationally.
For further information please contact:
Sinead Jordan, Neurology Research Nurse Manager
Phone: (01) 2213592
Irish Network for Children’s Clinical Research
in4kids – Irish Network for Children’s Clinical Research – is a national paediatric clinical research network whose aim is to build a strong network within Ireland to enhance collaboration amongst the paediatric research community in Ireland and to develop national capacity for high-quality, ethical paediatric clinical research. Our network membership is open to clinical research personnel from across the paediatric research community in Ireland.
For general enquiries email contact [at] in4kids [dot] ie
Visit the in4kids website.
HRB Mother & Baby Clinical Trials Network Ireland
The HRB Mother & Baby Clinical Trials Network Ireland (HRB M&B CTNI) is a new, exciting and unique partnership between the two most successful perinatal research entities currently operational in Ireland, INFANT and Perinatal Ireland.
This CTN represents a critical mass of obstetricians, neonatologists, midwives and allied professionals from seven of the largest maternity hospitals on the island of Ireland, which deliver over 55,000 babies per annum (almost three quarters of the total births on this island). Together, we have a strong track record in collaborative research and in the conduct of large-scale, international, multicentre, randomised controlled trials (RCTs) of diagnostics and interventions in pregnancy and neonates (e.g. PELICAN, IMPROvED, NEMO, TEST). In addition, we are acknowledged world leaders in longitudinal cohort studies such as ESPRiT, PORTO, GENESIS, SCOPE etc. and we have established and curate Ireland’s first birth cohort, BASELINE.
Perinatal disease accounts for nearly 10% of the global burden of disease. However, R&D investment in perinatal health remains small and nonstrategic; the number of registered pipeline drugs for perinatal conditions is only 1-5% of those for other major disease areas. One barrier to the development of better therapies and diagnostics for mothers and babies is the intrinsic complexity of conducting trials in these uniquely vulnerable populations and conducting long-term follow up. The Mother & Baby CTNI, built on a robust platform of existing collaborations and more than a decade of experience in the conduct of research in the perinatal population, will reverse this pattern.
The primary aim of the HRB M&B CTNI is to unite the combined experience of both the medical teams and resources in all centres. This combination provides a world class research infrastructure which is at the forefront of translation research regarding the transition of fundamental research into the clinical environment. HRB M&B CTNI has a balanced and extensive portfolio of both ‘home-grown’ and international clinical trials of novel interventions and diagnostics in pregnancy and neonates. The HRB M&B CTNI will facilitate greater national collaboration in the arena of perinatal trials and will ensure that Ireland maintains our place at the international forefront of this area of clinical research.
For all queries please contact:
Dr Liz Tully, Network Manager.
Email: email@example.com or Telephone: 01-4022540
Irish Centre for Fetal and Neonatal Translational Research (INFANT)
INFANT is focused on making pregnancy safer and improving health outcomes for mothers and babies on a global scale. The centre is based in Cork University Maternity Hospital and funded by Science Foundation Ireland. The centre is an international leader of discovery and innovation in perinatal healthcare, undertaking world-class collaborative research and partnering with a diverse array of national and international industries and academics.
INFANT addresses unmet worldwide clinical needs for effective screening tests for the most common complications of pregnancy and the most significant problems for newborns. One in five pregnancies is complicated by pre-eclampsia, pre-term birth or fetal growth restriction. These conditions can progress to serious illnesses for both mum and baby if they are left undetected. For the baby, birth is a perilous journey. Some 5% of newborns experience asphyxia at birth, which can later develop into brain injury and seizures. The creation of next- generation devices to facilitate point-of-care and remote monitoring and diagnostics will transform antenatal and neonatal healthcare and service delivery on a global level, and position Ireland at the forefront. Access to world-first technologies allows INFANT’s industry partners to deliver innovative solutions to global markets, creating exciting economic opportunities and delivering sustainable high knowledge value jobs in Ireland. Research areas include:
|• Innovative cot-side monitoring||• Perinatal clinical trials|
|• Medical devices||• Connected health|
|• Maternal and infant nutrition||• Monitoring platforms|
|• Biomarkers for screening and diagnostics in pregnancy|
Perinatal Ireland is a multi-centre research consortium which focuses on improving both women and children’s health all over Ireland. This improvement is achieved through the utilisation of advanced technologies including ultrasound which contributes to the enhanced detection and diagnosis levels in utero. Perinatal Ireland focuses primarily on areas of clinical improvement in women and children’s health such as intrauterine growth restriction (IUGR), discordant growth in twins, the prevention of stillbirth, prediction of preterm labour etc.
Perinatal Ireland has a unique position resulting from the access to large patient populations which facilitates innovative and ground-breaking clinical and translational research. Each member site of the consortium is equipped with dedicated ultrasound imaging equipment and software, with access to specialised expertise such as biostatistical support and a robust quality system. Perinatal Ireland has a strong track record in the conduct of national prospective observational studies such as the national twin study (ESPRIT) and the national growth restriction study (PORTO) whereby the knowledge gained from this research has proven beneficial to mother and babies across the island in the publication of national clinical care guidelines.
The consortium incorporates the main academic obstetric units across the island including The Rotunda Hospital (Dublin), The National Maternity Hospital (Holles St. Dublin), The Coombe Women and Infant’s University Hospital (Dublin), Cork University Maternity Hospital, University Maternity Hospital Limerick, University Hospital Galway, Royal Jubilee Maternity Hospital (Belfast).
For all queries please contact:
Dr Liz Tully, Network Manager.
Email: firstname.lastname@example.org or Telephone: 01-4022540
HRB Primary Care Clinical Trial Network Ireland
Primary care accounts for 90% of all health care contacts, with more than 20 million individual consultations annually in Ireland. GPs and other health care professionals working in the community make decisions every day on how to best treat the patients they meet: these decisions should be based on conclusive evidence, drawn from primary care.
The HRB Primary Care Clinical Trials Network Ireland is a collaborative partnership that brings together key people in Ireland to run clinical trials in primary care. Working closely with the public, with patients and with GPs and other healthcare professionals, the Network aims to improve individual patient health and health care by conducting high quality, internationally recognised, randomised trials in Irish primary care, addressing important and common problems.
Led by Professor Andrew Murphy, NUI Galway, the network includes a multidisciplinary team of colleagues from NUI Galway, Royal College of Surgeons in Ireland, Queen’s University Belfast and the Irish College of General Practitioners. In the Network, Irish researchers will:
- Lead new clinical trials in a number of areas, including a trial on the treatment of urinary tract infections and a second trial on potentially inappropriate prescribing in primary care
- Explore the potential of using trials to help improve the safety climate in primary care
- Develop a strong public and patient involvement in research and embed this approach at all steps in the research cycle
- Conduct studies within trials (SWATS) to improve the recruitment in trials in primary care
- Join international trials addressing important questions for patients in primary care
- Build research capacity and expertise among primary care teams, enabling them to become a central tenet in the primary care research infrastructure, contributing to improved individual patient health and health care
- Be a focal point of contact and of support for any research team or industrial sponsor who wants to conduct research in Irish primary care
For further information, please email email@example.com
HRB Centre for Primary Care Research
The HRB Centre for Primary Care Research (HRB CPCR) has been funded as a national research centre since 2008. It is a collaborative research group, led by the Department of General Practice, RCSI with colleagues from General Practice in NUIG, TILDA and General Practice in TCD and the School of Pharmacy in Queen’s University Belfast. The emphasis on the second phase of funding is to develop and assess information and communication technology to improve the quality and safety of patient care. The following clinical areas are being covered: safe and effective prescribing; chronic disease management in diabetes; rational antibiotic use in the community and the value of a summary care record.
For all queries please email: firstname.lastname@example.org
Irish College of General Practitioners (ICGP)
The research unit of the ICGP aims to develop and support research and audits in general practice in a structured and rigorous format. The overall aim of the research unit is to contribute to the knowledge base of general practice and to support evidence-based practice. The ICGP Research Ethics Committee, granted formal recognition on 17th May 2005, reviews both clinical and non-clinical trials. Developed as a collaboration between the ICGP, the HRB Centre for Primary Care Research (RCSI) and WestREN (NUIG), the Irish Primary Care Research Network (IPCRN) aims to establish a national network of Irish general practices whose purpose is to participate in audit and clinical research for the benefit of their patients and the Irish population.
For all queries please email: sallyanne.o’email@example.com
VINE: The Vasculitis Irish Network
VINE is a collaboration between five Irish centres, Vasculitis Ireland Awareness and the National Vasculitis Patient Organisation. The network comprises of dedicated multi-disciplinary centres that provide a coordinated care path for patients with primary systemic small vessel vasculitis (PSV), from diagnosis to relapse and on to long term remission. It provides access to clinical trials for patients with PSV. The five centres maintain close ties and difficult cases are often discussed in a cross centre forum.
To provide a foundation for developing the service in Ireland and to support translational vasculitis research, the VINE network has established the Irish RKD Registry and Biobank which seeks to enrol 900 patients in Ireland with PSV, providing a rich longitudinal clinical database, which is linked to one of the most complete PSV biobanks in the world based in Trinity College Dublin. Further details are provided below.
The network is closely aligned with UKIVAS, the Vasculitis Rare Disease Group of the UK and Ireland and the European Vasculitis Society.
For further information please contact:
Prof Mark Little, Trinity Health Kidney Centre, Tallaght Hospital
Rare Kidney Disease Registry and Biobank
The RKD registry and Biobank was established in 2012 and aims to address an unmet need in the study of rare kidney disease in Ireland including facilitation of clinical studies when sporadic cases are scattered throughout many hospitals in Ireland. As the principal investigator is prominent in the Systemic Vasculitis research arena, this condition is particularly strongly represented; some 350 cases have been recruited and sampled longitudinally, making this one of the most extensive vasculitis biobanks in the world.
The Registry is an integrated resource across AMNCH Hospital Tallaght, St James’s Hospital, Beaumont Hospital and Trinity College Dublin, with input from multiple other units across the country. It is funded by Science Foundation Ireland, Dublin Centre for Clinical Research, Trinity College MedDay and The Meath Foundation. Our goal in developing such a network is to link a robust patient registry (with capture of detailed longitudinal clinical data across multiple units) to collection of biological samples.
Respiratory and Asthma Research Network
The INCA™ Studies are a suite of clinical investigations. The focus of our research is in developing a novel technology which can be used in clinical practice as an objective assessment of patient adherence to inhaled therapy.
Arthritis Research Coalition
A recent report assessing rheumatology research excellence, measured by the number of citations per article published between 1996 and 2010, ranked Ireland 1st of the 35 richest countries. Major research outputs have included molecular studies on the pathogenesis of common rheumatic diseases, the discovery and validation of prognostic biomarkers, and clinical studies on novel therapies. These have relied on the recruitment of highly characterized patients populations and by the development of linked biorepositories of blood and synovial tissue.
Despite these successes the research activity has been reliant on a fragmented and poorly funded infrastructure. The development of national rheumatology research networks in many European countries including Britain, Sweden and The Netherlands highlights their value. The establishment of Arthritis Ireland chairs, and the development of a Dublin Centre of Excellence, will form the foundation of national rheumatology research strategy, however, the development of a research nurse network will seek to engage all clinicians, co-ordinate all research activities and ensure that Ireland remains on top.
The primary aim is recruit patients with common rheumatic diseases. and obtain biosamples that will underpin clinical research. A secondary aim is to increase national involvement in clinical trials of novel therapeutic agents.
The consortium lead is Prof Gerry Wilson. The leads by area are as follows:
Rheumatoid Arthritis – Prof Doug Veale
OA/Crystal arthritis – Prof Geraldine McCarthy
Spondyloarthropathies – Dr Barry O’Shea
Connective Tissue Diseases – Dr Grainne Murphy
Paediatrics – Dr Orla Killeen
Metabolic Bone- Dr John Carey
For further information:
TB Immunology Research, Institute of Molecular Medicine, TCD
The host response to tuberculosis is the main focus of TB Immunology Research at the Institute of Molecular Medicine, Trinity college Dublin. The scientists work closely with the clinical and public health tuberculosis service based in St. James’s Hospital, which is on the same campus as the Institute of Molecular Medicine. The scientists are addressing clinically relevant questions that seek to improve our understanding of the human host – TB pathogen interaction – to garner scientific advances that can inform better tests, treatments, vaccines for this global health emergency; and make newer immunotherapieutics safer.